布里奇特·福特博士.D.

生物学助理教授

Dr. 布丽姬特福特Dr. 布丽姬特福特 is an Assistant Professor in the Department of Biology at UIW. 她在圣. Mary’s University in Biological Sciences with a minor in Chemistry. 然后她继续获得了博士学位.D. in Molecular Medicine at UT Health San Antonio in 2012. She completed her postdoctoral fellowship training at the 美国陆军外科研究所 in the Extremity Trauma and Regenerative Medicine task area and at UT Health at San Antonio between the Magnetic Resonance Imaging Division and the Department of Medicine. 在这段时间里. 福特是圣乔治大学的兼职教授. Mary’s University and taught in the Biological Sciences, Chemistry and Exercise and Sports Science Departments.

Dr. 福特教授解剖学和生理学I和II, 普通生物学I和专业实验室, 细胞生物学, 以及uw内分泌学专题课程. She loves mentoring undergraduates in the research laboratory where her research focuses on understanding the molecular mechanisms involved in renal cell injury in diabetic kidney disease, with a particular emphasis on oxidative stress pathways.

联系信息

  • 2001-2005 B.A. 生物科学/化学(副修)，圣. 玛丽大学，圣安东尼奥，德克萨斯州
  • 2007-2012 Ph.D. Molecular Medicine, University of Texas Health Science Center at San Antonio,San Antonio, Texas
  • 2012 - 2014年博士后, Oak Ridge Institute for Science and Education Fellowship Award,美国陆军外科研究所,四肢创伤研究/再生医学
  • 2014 - 2017年博士后, 机构T32国家研究服务奖, UT Health Science Center at San Antonio Research Imaging Institute/MRI Division and Department of Medicine/Nephrology Division
  • 2018 Gross Anatomy Instructor, UT Health at San Antonio, Occupational Therapy Doctorate Program
  • 2017 – present Adjunct Assistant Professor, UT Health at San Antonio, Medicine Renal Diseases
  • 2017 – present Assistant Professor of Biology, 道成肉身的大学, Biology Department
  • 普通生物学I和专业实验
  • 《菠菜评级排行》第2321章
  • 《菠菜评级排行》第2322期
  • 细胞生物学
  • BIOL 4399专题:内分泌

糖尿病肾病, 或者糖尿病肾病, is a serious and life-threatening complication of type 1 and type 2 diabetes. Our current understanding of the mechanisms that regulate the initiation and progression of diabetic nephropathy is not sufficient to design effective therapies to prevent or reverse kidney damage. The Ford research laboratory explores mechanisms involved in kidney cell injury in diabetic nephropathy with a specific emphasis on oxidative stress, or cell injury due to the production of damaging compounds called oxygen radicals. One specific area that may be of great importance in designing new therapies f或者糖尿病肾病 is to identify factors that are implicated in the death of glomerular cells, 足细胞和系膜细胞, 导致随后的肾功能丧失.

Recent undergraduate trainees have mastered mammalian tissue culture and used various molecular methods such as real time PCR, 西方墨点法, 免疫细胞化学, ELISAs, and enzyme activity assays to identify factors involved in podocyte and mesangial cell injury using an in vitro model system mimicking the diabetic environment. 总体目标博士. Ford has for all of her trainees is to apply what they learn in the classroom to ask scientific questions in the quest to become independent and creative thinkers

同行评议期刊文章

Eid AA, Gorin Y， Fagg BM， Maalouf R, Barnes JL, Block K, Abboud HE. Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases. Diabetes. 58(5):1201-1211, 2009. PMCID: PMC2671039

Eid AA, Ford BM, Block K, Kasinath BS, Gorin Y, Choudhury GG, Barnes JL, Abboud HE. AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes. J Biol Chem. 85(48):37503-12, 2010. PMCID: PMC2988355

Eid AA, Ford BM, Bhandary B, Cavagliery R, Block K, Barnes JL, Gorin Y, Choudhury GG, Abboud HE. Mammalian target of rapamycin regulates Nox4-mediated podocyte depletion in diabetic renal injury. Diabetes. 62(8):2935-47, 2013. PMCID: PMC3717863

Ford BM, Eid AA, Gooz M, Barnes JL, Gorin YC, Abboud HE. ADAM17 mediates Nox4 expression and NADPH oxidase activity in the kidney cortex of OVE26 mice. J是肾物理吗. 305(3):F323-32, 2013. PMCID: PMC3742865

Chandra SB, Mohan S， Ford BM，黄磊，Janardhanan P, Deo KS, Muir ER, dutq. Targeted Overexpression of endothelial nitric oxide synthase in endothelial cells improves cerebrovascular reactivity in Ins2 Akita1型糖尿病小鼠. [J]脑血流机制. 2015年10月接受. [预印]PMID: 26661212

Chowdhury K, Kumar S, Sharma A, Bhagat M, Kamai A， Ford BM * ， Asthana S, Mandal CC. Presence of a consensus DNA motif at nearby DNA sequence of the mutation susceptible CG nucleotides. Gene. 639:85-95, 2018. PMID: 289863

Do C, Ford BM*，李德良，谭超，陈建平，陈建平. Gadolinium-based contrast agents: Stimulators of myeloid-induced renal fibrosis and major metabolic disruptors. 苹果毒理学(2019). DOI: 10.1016/j.taap.2019.05.009中:31082427.

Bandyopadhayaya年代, Ford BM*和Mandal CC. 冷血:患癌风险的冷应激案例. 临床病理学杂志. 2019年3月提交

选择的抽象

2018 Penn R **, Ford BM, Smith HA. “Investigation of P-Glycoprotein (PGP) Induction by PGP Substrates to Induce Paclitaxel Resistance in Ovarian Cancer Cells.“第11届UIW年度研究周

2018 Ford BM, Wauquier F, Feliers, D, Ma R, Choudhury GG, Barnes JL, Dupuy C, Bae YS, Lee DY, Gorin YC. “Calcium-dependent dual oxidase 2 is a novel mediator of oxidative stress and mesangial cell fibrotic injury in response to angiotensin II: Role of Nox4.” 21st Annual Medicine Research Day; UT Health at San Antonio, May 22, 2018

2018 Aguilar E **，纳瓦罗 ** , Ford BM, Wauquier F , 李，DY，戈林，YC . “Novel role of dual oxidase 2 as a mediator of podocyte injury in the diabetic environment.2018年SACNAS全国STEM多样性会议

2018 Ramirez-Pedroza A **马丁内斯·A **, Ford BM, 华奎尔F，李，DY，戈林YC. “Calcium-dependent dual oxidase 2 is a novel source of reactive oxygen species implicated in glomerular mesangial cell fibrotic response to angiotensin II.2018年SACNAS全国STEM多样性会议

2019亚伯拉罕SM **，纳瓦罗 **， Wauquier FM, Lee DY, Gorin YC， Ford BM. “Novel role of dual oxidase 2 as a mediator of podocyte injury in the diabetic environment,” 2019. FASEB Journal 33 (1_supplement)， 567.11-567.11实验生物学会议，奥兰多，佛罗里达.

Ramirez-Pedroza A **马丁内斯·A **, Ford BM, 华奎尔F，李，DY，戈林YC. “Calcium-dependent dual oxidase 2 is a novel source of reactive oxygen species implicated in glomerular mesangial cell fibrotic response to angiotensin II,” 2019. FASEB Journal 33 (1_supplement)， 567.13-567.13实验生物学会议，奥兰多，佛罗里达.

在这里查看完整的出版物列表

邀请谈判

2017 “Novel role of dual oxidase 2 as a mediator of glomerular cell injury in diabetes.” Pathology Research Conference, UT Health San Antonio, Texas

2019 “Role of dual oxidase 2 and NADPH oxidases in diabetic kidney disease." Department of Medicine Research Discussions, UT Health San Antonio, Texas