克里斯托弗·皮尔斯博士.D.

• Ph.D. Cell and Molecular Biology, 德克萨斯大学圣安东尼奥分校, 2012
• M.S. 生物学，德克萨斯大学圣安东尼奥分校，2007年
• B.S. 生物学，密苏里南州立大学，2005年

• Assistant Professor, Department of Biology, 道成肉身的大学, 2015 – Present
• 博士后研究员, Department of Biology and the South Texas Center for Emerging Infectious Diseases (STCEID), 德克萨斯大学圣安东尼奥分校, 2013 – 2015

• biol1402 -普通生物学专业I
• BIOL 2474 -微生物学和实验室入门
• BIOL 3202 – Research Methods in Cell and Molecular Genetics
• biol3311 -细胞生物学
• BIOL 4399 -专题:医学真菌学

Dr. 皮尔斯研究真菌, 白色念珠菌, 哪一种能引起疾病, 尤其是免疫功能低下的患者. Candida infections are the fourth most common nosocomial, or hospital-acquired, infection. The seriousness of these infections is heightened with unacceptably high mortality and the limited number of antifungal drugs. Dr. Pierce’s research has been focused on understanding the role of biofilm formation and filamentation in C. albicans infections and the development of novel agents targeting these virulence factors associated with infection.

Dr. Pierce’s current research interests lie in identifying and subsequently characterizing the activity of anti-biofilm and anti-filamentation compounds, with emphasis on minimizing the potential to induce resistance. The main components of his research are: (i) Identify anti-virulence compounds from commercially available small molecule libraries. These libraries represent a promising arsenal of potential antifungal candidates that can be screened for inhibition of biofilm formation and filamentation. (ii) Characterize the mechanism(-s) of action of the identified inhibitors of biofilm formation and filamentation. These studies include the effects of compounds on global mechanisms of biofilm formation (adhesion, 扩散, 和成熟), 药物联合研究, 耐药性测定的发展, 细胞毒性检测, 以及分子靶标的鉴定.

Dr .的环境. Pierce’s laboratory at UIW is focused on training and developing undergraduate students as independent researchers. Dr. 皮尔斯在实验室指导过很多学生. Students in the lab have presented their work at UIW Research Week, as well as, 地区和州会议. 指导学生, 无论是在教室里, 研究实验室或科学会议, 是博士之一. 皮尔斯的激情.

选定的主要研究文章

• Romo, J.A., C.G. Pierce, M. Esqueda, C.Y. Hung, S.P. 萨维尔和J.L. Lopez-Ribot (2018) In vitro characterization of biaryl amide anti-virulence compound targeting 白色念珠菌 filamentation and biofilm formation. 前细胞感染微生物. doi: 10.3389/fcimb.2018.00227
• Garner, R.N., C.G. Pierce, C.R. 里德和W.W. Brennessel. (2017) Photoinitiated treatment of Mycobacterium using Ru (II) isoniazid complexes. [j] .中国生物医学工程学报(英文版).
• Romo, J.A.*, C.G. Pierce*, A.K. 查图尔维迪,.L. Lazzell, S.F. McHardy, S.P. 萨维尔和J.L. Lopez-Ribot (2017) Development of anti-virulence approaches for candidiasis via a novel series of small-molecule inhibitors of 白色念珠菌 filamentation. mBio 8: e01991-17. http://doi.org/10.1128/mBio.01991-17. *J.A.R. and C.G.P. 对这项工作贡献相同.
• Pierce, C.G., A.K. 查图尔维迪,.L. Lazzell, A.T. Powell, S.P. Saville, S.F. 麦克哈迪和J.L. Lopez-Ribot. (2015) A novel small molecule inhibitor of 白色念珠菌 biofilm formation, filamentation and virulence with low potential for the development of resistance. [j] .中国生物工程学报(英文版)1 (5):591 - 591. Doi 10.1038 / npjbiofilms.2015.12.
• Pierce, C.G., S.P. 萨维尔和J.L. Lopez-Ribot. (2014) High content phenotypic screenings to identify inhibitors of 白色念珠菌 biofilm formation and filamentation. 中国生物医学工程学报(英文版)，30 (3):423- 431.
• Pierce, C.G., D.P. 托马斯和J。.L. Lopez-Ribot (2009) Effect of tunicamycin on 白色念珠菌 biofilm formation and maintenance. 中国生物医学工程学报，30 (3):493 - 493.
• Pierce, C.G., P. Uppuluri,.R. 特里斯坦,F.L. Wormley E. Mowat, G. Ramage和J.L. Lopez-Ribot. (2008) A simple and reproducible 96-well plate-based method for the formation of fungal biofilms and its application to antifungal susceptibility testing. 自然学报3:1494-1500.

精选综述文章

• Pierce, C.G., T. Vila, J.A. Romo, D. Montelongo-Jauregui G. Wall, A. Ramasubramanian和J.L. Lopez-Ribot (2017) The 白色念珠菌 biofilm matrix: Composition, structure and function. 真菌学报3(14):doi:10.3390 / jof3010014
• Pierce, C.G., A. Srinivasan,.K. Ramasubramanian和J.L. Lopez-Ribot. (2015) From biology to drug development: New approaches to combat the threat of fungal biofilms. 微生物学快报3(3):MB-0007-2014. doi:10.1128 / microbiolspec.MB-0007-2014.
• Pierce, C.G., A. Srinivasan,., P. Uppuluri,.K. Ramasubramanian和J.L. Lopez-Ribot. (2013) Antifungal therapy with an emphasis on biofilms. 当前意见药理学13(5):726-30.

精选出版的摘要和报告

• Winski, C.J., H. 阿尔瓦雷斯和C.G. Pierce (2019) Overcoming 白色念珠菌 drug resistant biofilms with Hsp90 Inhibitors. Texas 本科 Research Days, Texas State Capitol, Austin, Texas.
• Nieto, B.L. and C.G. Pierce (2018) Antibiofilm of Chloroxine and Oligomycin A against 白色念珠菌. Annual Biomedical Research Conference for 本科s, Indianapolis, Indiana.
• Armstrong-VanLaar, M.R. and C.G. Pierce (2018) Screening of NIH Clinical Collection Library for Inhibitors of 白色念珠菌 Biofilms. Annual Biomedical Research Conference for 本科s, Indianapolis, Indiana.
• Alvarez, H., C.J. Winski，和C.G. Pierce (2018) Overcoming 白色念珠菌 drug resistant biofilms with Hsp90 Inhibitors. Annual Biomedical Research Conference for 本科s, Indianapolis, Indiana.
• Winski, C.J., C.J. Montez, D.A. Santos, C.G. 皮尔斯和R.N. Garner (2018) Photoinduced Delivery of Para-aminosalicylic Acid (PAS) using Ru(II) Complexes for the Treatment of Mycobacterium Infections. Annual Biomedical Research Conference for 本科s, Indianapolis, Indiana.
• Garcia, I., A.I. Knecht, C.R. 汤普森和C.G. Pierce (2018) Anti-Biofilm Activity of Chloroxine against 白色念珠菌. Texas Branch American Society of Microbiology Meeting, New Braunfels, Texas.
• Valadez, C., D. Zarate, A. 选C.G. Pierce (2018) Identification and Characterization of Two Soil Bacteria Isolates Displaying Antimicrobial Activity. Texas Branch American Society of Microbiology Meeting, New Braunfels, Texas.
• Knecht, A.I, and C.G. Pierce (2017) Identification and Characterization of Novel Compound Inhibitors of 白色念珠菌 Biofilm Formation. 德克萨斯州科学院，贝尔顿，德克萨斯州.
• 汤普森,C.R., and C.G. Pierce (2017) Screening of NIH Clinical Collection Library for Compounds with 白色念珠菌 Anti-Biofilm Activity. 德克萨斯州科学院，贝尔顿，德克萨斯州.
• Knecht, A.I, R.L. Estolano和C.G. Pierce (2017) Identification and Characterization of Novel Compound Inhibitors of 白色念珠菌 Biofilm Formation. 道成肉身的大学 Research Week, San Antonio, Texas.